基于CiteSpace的老年抑郁症与肠道菌群研究文献计量及可视化分析

doi:10. 3969 / j. issn. 2096-2266. 2026. 04. 007

摘要/Abstract

摘要： 目的：对老年抑郁症与肠道菌群相关文献进行计量学分析，系统评估该领域的发展趋势、合作网络结构、知识基础
及研究热点演化。方法：检索Web of Science核心合集数据库2005年1月至2025年12月相关文献，纳入英文原创性研究论
文或综述型文献486篇。采用CiteSpace 6.4.R1软件构建国家、研究机构、作者合作网络、共被引网络及关键词共现网络，采
用突现检测算法识别研究前沿。结果：发文量呈阶段性增长，2024年达峰值（87篇，占17.9%）。共有61个国家和286家研
究机构参与相关研究，美国发文量位居首位且中心性最高（126 篇，中心性0.40），中国发文量位居第二但国际合作薄弱
（119篇，中心性0.02）。共有328位作者参与研究，高产作者中心性均为0.00，呈碎片化特征。共被引文献形成13个知识聚
类（Silhouette 值均大于0.85），涵盖菌群失调与代谢、情感障碍、神经发育和炎症衰老等主题。关键词突现分析显示研究焦
点从现象描述（“intestinal microbiota”，强度3.61）向机制探索（“gut brain axis”，强度2.76）和方法学验证（“validity”，强度
2.94）演进。结论：2005至2025年老年抑郁症与肠道菌群研究经历了从现象描述到机制探索再到临床转化的演进历程，研
究网络呈现“强核心弱边缘”结构，国际合作有待加强。认知损害、性别差异和疾病谱扩展可能成为未来重要的研究方向，
为基于微生态特征的老年抑郁症个体化诊疗提供了新思路。

关键词: 老年抑郁症, 肠道菌群, 肠-脑轴, 文献计量学

Abstract: Objective：To analyze the development trends, cooperative network structure, knowledge base and evolution of research
hotspots in studies concerning depression in older adults and gut microbiota through bibliometric and visualization methods, and to pro⁃
vide references for future research. Methods: Relevant publications indexed in the Web of Science Core Collection from January 2005
to December 2025 were retrieved. A total of 486 original research articles and review articles were included. CiteSpace 6.4.R1 software
was used to construct collaboration networks of countries, institutions, and authors, co-citation networks, and keyword co-occurrence
networks, and to identify research frontiers via burst detection. Results: Publication output showed a phased increase, peaking in 2024
with 87 papers (17.9% of total). A total of 61 countries and 286 institutions contributed to this field. The United States ranked first in
both publication volume and centrality(126 papers, centrality 0.40), whereas China ranked second (119 papers) but had a low centrality
(0.02). A total of 328 authors participated, with highly productive authors all showing a centrality of 0.00, indicating fragmented collabo⁃
ration. Co-citation analysis formed 13 knowledge clusters (Silhouette values all > 0.85), covering topics such as dysbiosis and metabo⁃
lism, affective disorders, neurodevelopment, and inflammatory aging. Burst detection showed an evolution of research foci from descrip⁃
tive phenomena ("intestinal microbiota", strength 3.61) to mechanistic exploration ("gut brain axis", strength 2.76) and methodological
validation ("validity", strength 2.94). Conclusion: From 2005 to 2025, research on older adults depression and gut microbiota has
evolved from phenomenological description to mechanistic exploration and then to clinical translation. The research network exhibits a
"strong core-weak periphery" structure, and international collaboration needs to be strengthened. Cognitive impairment, gender differ⁃
ences, and expansion of disease spectrum may emerge as important future research directions, providing new insights for personalized
diagnosis and treatment of geriatric depression based on microbiome characteristics.

Key words: older adults depression, gut microbiota, gut-brain axis, bibliometric analysis

中图分类号:

R749

陈梓甄, 袁芝琼, 张　晓, 姬思宇, 郭守霞, 郭清华, 李丽娟. 基于CiteSpace的老年抑郁症与肠道菌群研究文献计量及可视化分析[J]. 大理大学学报, 2026, 11(4): 42-54.

Chen Zizhen¹, Yuan Zhiqiong¹, Zhang Xiao², Ji Siyu¹, Guo Shouxia¹, Guo Qinghua¹, Li Lijuan¹. Bibliometric and Visual Analysis of Research on Depression in Older Adults and Gut Microbiota Based#br# on CiteSpace[J]. Journal of Dali University, 2026, 11(4): 42-54.

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链接本文: http://journal15.magtechjournal.com/Jwk_dlxyzk/CN/10. 3969 / j. issn. 2096-2266. 2026. 04. 007

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